| 2024 |
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Preventive Effects of Dental Pulp Stem Cell-conditioned Media on Anti-RANKL Antibody-Related Osteonecrosis of the Jaw. Kaminogo K, Yamaguchi S, Chen H, Yagita H, Toyama N, Urata Y, Hibi H. Calcif Tissue Int. 2024 Aug;115(2):185-195. doi: 10.1007/s00223-024-01232-1. Epub 2024 May 29. PMID: 38809297. Free PMC article.
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Blockade of CD80/CD86-CD28 co-stimulation augments the inhibitory function of peptide antigen-specific regulatory T cells. Maehara Y, Takeda K, Tsuji-Yogo K, Morimoto K, Harada M, Kuriyama K, Hirota S, Yagita H, Okumura K, Uchida K. Biomed Res. 2024;45(3):115-123. doi: 10.2220/biomedres.45.115. PMID: 38839354. Free article.
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Local treatment of HVJ-E with T cell costimulatory molecule stimulation elicits systemic anti-tumor effects. Ishibashi A, Li Y, Hisatomi Y, Ohta N, Uegaki Y, Tanemura A, Ohashi R, Kitamura K, Saga K, Yoshimura Y, Inubushi S, Ishida K, Iwabuchi S, Hashimoto S, Kiyohara E, Yagita H, Kaneda Y, Nimura K. Mol Ther Oncol. 2024 Oct 10;32(4):200893. doi: 10.1016/j.omton.2024.200893. eCollection 2024 Dec 19. PMID: 39534532. Free PMC article.
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| 2023 |
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Fibroblast growth factor 18 stimulates the proliferation of hepatic stellate cells, thereby inducing liver fibrosis. Tsuchiya Y, Seki T, Kobayashi K, Komazawa-Sakon S, Shichino S, Nishina T, Fukuhara K, Ikejima K, Nagai H, Igarashi Y, Ueha S, Oikawa A, Tsurusaki S, Yamazaki S, Nishiyama C, Mikami T, Yagita H, Okumura K, Kido T, Miyajima A, Matsushima K, Imasaka M, Araki K, Imamura T, Ohmuraya M, Tanaka M, Nakano H. Nat Commun. 2023 Oct 9;14(1):6304. doi: 10.1038/s41467-023-42058-z. PMID: 37813881. Free PMC article.
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A high-sensitivity ELISA for detection of human FGF18 in culture supernatants from tumor cell lines. Tsuchiya Y, Komazawa-Sakon S, Tanaka M, Kanokogi T, Moriwaki K, Akiba H, Yagita H, Okumura K, Entzminger KC, Okumura CJ, Maruyama T, Nakano H. Biochem Biophys Res Commun. 2023 Oct 1;675:71-77. doi: 10.1016/j.bbrc.2023.06.070. Epub 2023 Jul 7. PMID: 37453260.
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| 2022 |
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Dietary Lactobacillus-Derived Exopolysaccharide Enhances Immune-Checkpoint Blockade Therapy Kawanabe-Matsuda H, Takeda K, Nakamura M, Makino S, Karasaki T, Kakimi K, Nishimukai M, Ohno T, Omi J, Kano K, Uwamizu A, Yagita H, Boneca IG, Eberl G, Aoki J, Smyth MJ, Okumura K. Cancer Discov. 2022 May 2;12(5):1336-1355. doi: 10.1158/2159-8290.CD-21-0929. PMID: 35180303 Free PMC article.
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cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis. Wang L, Jin H, Jochems F, Wang S, Lieftink C, Martinez IM, De Conti G, Edwards F, de Oliveira RL, Schepers A, Zhou Y, Zheng J, Wu W, Zheng X, Yuan S, Ling J, Jastrzebski K, Santos Dias MD, Song JY, Celie PNH, Yagita H, Yao M, Zhou W, Beijersbergen RL, Qin W, Bernards R. Nat Cancer. 2022 Nov;3(11):1284-1299. doi: 10.1038/s43018-022-00462-2. Epub 2022 Nov 22. PMID: 36414711.
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Chemical augmentation of mitochondrial electron transport chains tunes T cell activation threshold in tumors. Dotsu Y, Muraoka D, Ogo N, Sonoda Y, Yasui K, Yamaguchi H, Yagita H, Mukae H, Asai A, Ikeda H.
J Immunother Cancer. 2022 Feb;10(2):e003958. doi: 10.1136/jitc 2021-003958. PMID: 35115364. Free PMC article.
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The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1
Li H, Xiao Y, Li Q, Yao J, Yuan X, Zhang Y, Yin X, Saito Y, Fan H, Li P, Kuo WL, Halpin A, Gibbons DL, Yagita H, Zhao Z, Pang D, Ren G, Yee C, Lee JJ, Yu D. Cancer Cell. 2022 Jan 10;40(1):36-52.e9. doi: 10.1016/j.ccell.2021.11.002. Epub 2021 Nov 24. PMID: 34822775 Free PMC article.
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| 2021 |
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IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells. Takumi Itoh, Ryo Hatano, Yoshiya Horimoto, Taketo Yamada, Dan Song, Haruna Otsuka, Yuki Shirakawa, Shuji Matsuoka, Noriaki Iwao, Thomas M. Aune, Nam H. Dang, Yutaro Kaneko, Ko Okumura, Chikao Morimoto, Kei Ohnuma. Cell Death & Disease. 2021;12:520. doi: 10.1038/s41419-021-03760-4. PMID: 34108587. Free PMC article.
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A New CD10 Antibody Inhibits the Growth of Malignant Mesothelioma. Mizutani N, Abe M, Kajino K, Matsuoka S. Monoclon Antibodies in Immunodiagnosis and Immunother. 2021 Feb;40(1):21-27. doi: 10.1089/mab.2020.0033. PMID: 33625287. FreePMC article.
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Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer
Nishina T, Deguchi Y, Ohshima D, Takeda W, Ohtsuka M, Shichino S, Ueha S, Yamazaki S, Kawauchi M, Nakamura E, Nishiyama C, Kojima Y, Adachi-Akahane S, Hasegawa M, Nakayama M, Oshima M, Yagita H, Shibuya K, Mikami T, Inohara N, Matsushima K, Tada N, Nakano H.
Nat Commun. 2021 Apr 16;12(1):2281. doi: 10.1038/s41467-021-22450-3. PMID: 33863879 Free PMC article.
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The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1
Li H, Xiao Y, Li Q, Yao J, Yuan X, Zhang Y, Yin X, Saito Y, Fan H, Li P, Kuo WL, Halpin A, Gibbons DL, Yagita H, Zhao Z, Pang D, Ren G, Yee C, Lee JJ, Yu D. Cancer Cell. 2022 Jan 10;40(1):36-52.e9. doi: 10.1016/j.ccell.2021.11.002. Epub 2021 Nov 24. PMID: 34822775 Free PMC article.
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| 2020 |
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The therapeutic strategy of drug re-positioning to induce autophagic cell death in brain malignancy. Yoshida GJ. Apoptosis. 2020 Aug;25(7-8):457-458. doi: 10.1007/s10495-020-01617-1. Epub 2020 Jun 24. PMID: 32583319.
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Applications of patient-derived tumor xenograft models and tumor organoids.Yoshida GJ. J Hematol Oncol. 2020 Jan 7;13(1):4. doi: 10.1186/s13045-019-0829-z. PMID: 31910904.
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Regulation of heterogeneous cancer-associated fibroblasts: the molecular pathology of activated signaling pathways. Yoshida GJ. J Exp Clin Cancer Res. 2020 Jun 16;39(1):112. doi: 10.1186/s13046-020-01611-0. PMID: 32546182.
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Photo effect on the CD1d-binding ability of azobenzene-attached analogues of α-GalCer. Kanamori T, Numata T, Kuwabara S, Ishii Y, Watarai H, Yuasa H.Bioorg Med Chem Lett. 2020 Mar 1;30(5):126960. doi: 10.1016/j.bmcl.2020.126960. Epub 2020 Jan 11. PMID: 31982233.
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Microsatellite instability and mismatch repair protein expressions in lymphocyte-predominant breast cancer Horimoto Y, Thinzar Hlaing M, Saeki H, Kitano S, Nakai K, Sasaki R, Kurisaki-Arakawa A, Arakawa A, Otsuji N, Matsuoka S, Tokuda E, Arai M, Saito M. Cancer Sci. 2020 Jul;111(7):2647-2654. doi: 10.1111/cas.14500. Epub 2020 Jun 13. PMID: 32449246
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IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells Takumi Itoh, Ryo Hatano, Yoshiya Horimoto, Taketo Yamada, Dan Song, Haruna Otsuka, Yuki Shirakawa, Shuji Mastuoka, Noriaki Iwao, Thomas M. Aune, Nam H. Dang, Yutaro Kaneko, Ko Okumura, Chikao Morimoto & Kei Ohnuma Cell Death & Disease 2021 volume 12, Article number: 520
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The EGFL7-ITGB3-KLF2 axis enhances survival of multiple myeloma in preclinical models. Salama Y, Andries H, Yokoyama K,T akahashi S ,Hattori K, Heissig B. Blood Adv. 2020 4(6) 1021 1037 doi:10.1182/ bloodadvances. 2019001002
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Photo effect on the CD1d-binding ability of azobenzene-attached analogues of α-GalCer. Kanamori T, Numata T, Kuwabara S, Ishii Y, Watarai H, Yuasa H. Bioorg Med Chem Lett. 2020 Mar 1;30(5):126960. doi: 10.1016/j.bmcl.2020.126960. Epub 2020 Jan 11. PMID: 31982233
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Applications of patient-derived tumor xenograft models and tumor organoids. Yoshida GJ. J Hematol Oncol. 2020 Jan 7;13(1):4. doi: 10.1186/s13045-019-0829-z. PMID: 31910904
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| 2019 |
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Vasculitis and crescentic glomerulonephritis in a newly established congenic mouse strain derived from ANCA-associated vasculitis-prone SCG/Kj mice. Hamano Y, Ito F, Suzuki O, Koura M, Matsuoka S, Kobayashi T, Sugitani Y, Wali N, Koyanagi A, Hino O, Suzuki S, Sugamata R, Yoshizawa H, Yumura W, Maruyama N, Kameoka Y, Noda Y, Hasegawa Y, Arai T, Suzuki K. Autoimmunity. 2019 Aug-Sep;52(5- 6):208-219. doi: 10.1080/08916934.2019.1658191. Epub 2019 Sep 2. PMID: 31476889
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Development of novel monoclonal antibodies with specific binding affinity for denatured human CD26 in formalin-fixed paraffin-embedded and decalcified specimens. Hatano R, Yamada T, Madokoro H, Otsuka H, Komiya E, Itoh T, Narita Y, Iwata S, Yamazaki H, Matsuoka S, Dang NH, Ohnuma K, Morimoto C. PLoS One. 2019 Jun 13;14(6):e0218330. doi: 10.1371/journal.pone.0218330. eCollection 2019. PMID: 31194830
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Biological Effects of IL-26 on T Cell-Mediated Skin Inflammation, Including Psoriasis. Itoh T, Hatano R, Komiya E, Otsuka H, Narita Y, Aune TM, Dang NH, Matsuoka S, Naito H, Tominaga M, Takamori K, Morimoto C, Ohnuma K.J Invest Dermatol. 2019 Apr;139(4):878-889. doi: 10.1016/j.jid.2018.09.037. Epub 2018 Nov 10. PMID: 30423328
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| 特許 |
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① 特許 WO2012046745A1 ¬ Mhcクラ スIIを 発現する 悪性腫瘍の治療薬 (国際特許)


② 特許 抗C D10 (国内特許) 2022年01月04日特許第7002145
申請済(下記2件)
① 上記 特許 WO2012046745A1のVariant抗体
② NKリンパ腫を傷害する抗体
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